Extractive Spectrophotometric Determination of Amitriptyline Hydrochloride in Pure and Pharmaceutical Formulations
نویسنده
چکیده
A sensitive, reproducible and accurate spectrophotometric method has been developed for determining amitriptyline hydrochloride (ATH) from its pharmaceutical formulation based on solvent extraction into chloroform of the product formed with 1, 2-naphthoquinon-4-sulphonate. The reaction and extraction was complete and quantitative at pH 1.3. The Beer’s law of yellow colored species is obeyed in the range of concentration of 2 – 18 μg ml-1 at the maximum absorption of 450 nm. The molar absorptivity and Sandell’s sensitivity values were found to be of 3.2382 x 103 l mol-1 cm-1 and 0.9615 μg cm-2 respectively. The results compare favourably with those of official methods. The method is successfully employed for the determination of ATH in pharmaceutical preparations.
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